Hypoxia-induced Downregulation of SRC-3 Suppresses Trophoblastic Invasion and Migration Through Inhibition of the AKT/mTOR Pathway: Implications for the Pathogenesis of Preeclampsia

Preeclampsia (PE) is characterized by poor placentation, consequent on aberrant extravillous trophoblast (EVT) cell function during placental development. The SRC family of proteins is important during pregnancy, especially SRC-3, which regulates placental morphogenesis and embryo survival. Although...

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Bibliographic Details
Published in:	Sci Rep
Main Authors:	He, Chengjin, Shan, Nan, Xu, Ping, Ge, Huisheng, Yuan, Yu, Liu, Yangming, Zhang, Pu, Wen, Li, Zhang, Fumei, Xiong, Liling, Peng, Chuan, Qi, Hongbo, Tong, Chao, Baker, Philip N.
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group UK 2019
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6637123/ https://ncbi.nlm.nih.gov/pubmed/31316078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46699-3
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Hypoxia-induced Downregulation of SRC-3 Suppresses Trophoblastic Invasion and Migration Through Inhibition of the AKT/mTOR Pathway: Implications for the Pathogenesis of Preeclampsia

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