Hypoxia-induced Downregulation of SRC-3 Suppresses Trophoblastic Invasion and Migration Through Inhibition of the AKT/mTOR Pathway: Implications for the Pathogenesis of Preeclampsia

Preeclampsia (PE) is characterized by poor placentation, consequent on aberrant extravillous trophoblast (EVT) cell function during placental development. The SRC family of proteins is important during pregnancy, especially SRC-3, which regulates placental morphogenesis and embryo survival. Although...

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Publicado en:Sci Rep
Autores principales: He, Chengjin, Shan, Nan, Xu, Ping, Ge, Huisheng, Yuan, Yu, Liu, Yangming, Zhang, Pu, Wen, Li, Zhang, Fumei, Xiong, Liling, Peng, Chuan, Qi, Hongbo, Tong, Chao, Baker, Philip N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637123/
https://ncbi.nlm.nih.gov/pubmed/31316078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46699-3
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