Glucagon up‐regulates hepatic mitochondrial pyruvate carrier 1 through cAMP‐responsive element‐binding protein; inhibition of hepatic gluconeogenesis by ginsenoside Rb1

BACKGROUND AND PURPOSE: Hepatic mitochondrial pyruvate carrier (MPC) transports pyruvate into mitochondria. This study investigated the involvement of MPC1 in hepatic glucagon response, in order to identify a possible pharmacological intervention. EXPERIMENTAL APPROACH: The correlation between hepat...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Lou, Meng‐Die, Li, Jia, Cheng, Yao, Xiao, Na, Ma, Gaoxiang, Li, Ping, Liu, Baolin, Liu, Qun, Qi, Lian‐Wen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637041/
https://ncbi.nlm.nih.gov/pubmed/31166615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14758
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