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Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis
Lysosomal exocytosis is a ubiquitous process negatively regulated by neuraminidase 1 (NEU1), a sialidase mutated in the glycoprotein storage disease sialidosis. In Neu1(−/−) mice, excessive lysosomal exocytosis is at the basis of disease pathogenesis. Yet, the tissue-specific molecular consequences...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Sci Adv |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Association for the Advancement of Science
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6636989/ https://ncbi.nlm.nih.gov/pubmed/31328155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav3270 |
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