TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma

Checkpoint blockade can reverse T-cell exhaustion and promote antitumor responses. Although blocking the PD-1 pathway has been successful in Hodgkin lymphoma, response rates have been modest in B-cell non-Hodgkin lymphoma (NHL). Coblockade of checkpoint receptors may therefore be necessary to optimi...

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Publicado no:Cancer Immunol Res
Main Authors: Josefsson, Sarah E., Beiske, Klaus, Blaker, Yngvild N., Førsund, Mette S., Holte, Harald, Østenstad, Bjørn, Kimby, Eva, Köksal, Hakan, Wälchli, Sébastien, Bai, Baoyan, Smeland, Erlend B., Levy, Ronald, Kolstad, Arne, Huse, Kanutte, Myklebust, June H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636339/
https://ncbi.nlm.nih.gov/pubmed/30659053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0351
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