TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma

Checkpoint blockade can reverse T-cell exhaustion and promote antitumor responses. Although blocking the PD-1 pathway has been successful in Hodgkin lymphoma, response rates have been modest in B-cell non-Hodgkin lymphoma (NHL). Coblockade of checkpoint receptors may therefore be necessary to optimi...

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Publicat a:Cancer Immunol Res
Autors principals: Josefsson, Sarah E., Beiske, Klaus, Blaker, Yngvild N., Førsund, Mette S., Holte, Harald, Østenstad, Bjørn, Kimby, Eva, Köksal, Hakan, Wälchli, Sébastien, Bai, Baoyan, Smeland, Erlend B., Levy, Ronald, Kolstad, Arne, Huse, Kanutte, Myklebust, June H.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636339/
https://ncbi.nlm.nih.gov/pubmed/30659053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0351
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