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Optimization of peptidic HIV‐1 fusion inhibitor T20 by phage display
The HIV fusion inhibitor T20 has been approved to treat those living with HIV/AIDS, but treatment gives rise to resistant viruses. Using combinatorial phage‐displayed libraries, we applied a saturation scan approach to dissect the entire T20 sequence for binding to a prefusogenic five‐helix bundle (...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6635768/ https://ncbi.nlm.nih.gov/pubmed/31228294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3669 |
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