Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2): IDENTIFICATION OF SELECTIVE INHIBITORS OF COLLAGENASE-1 (METALLOPROTEINASE 1 (MMP-1))

Tissue inhibitor of metalloproteinases-2 (TIMP-2) is a broad spectrum inhibitor of the matrix metalloproteinases (MMPs), which function in extracellular matrix catabolism. Here, phage display was used to identify variants of human TIMP-2 that are selective inhibitors of human MMP-1, a collagenase wh...

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Main Authors: Bahudhanapati, Harinath, Zhang, Yingnan, Sidhu, Sachdev S., Brew, Keith
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173135/
https://ncbi.nlm.nih.gov/pubmed/21715326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253328
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