ERK1/2 Mitogen-Activated Protein Kinase Phosphorylates Sodium Channel Na(v)1.7 and Alters Its Gating Properties

Na(v)1.7 sodium channels can amplify weak stimuli in neurons and act as threshold channels for firing action potentials. Neurotrophic factors and pro-nociceptive cytokines that are released during development and under pathological conditions activate mitogen-activated protein kinases (MAPKs). Previ...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Stamboulian, Severine, Choi, Jin-Sung, Ahn, Hye-Sook, Chang, Yu-Wen, Tyrrell, Lynda, Black, Joel A., Waxman, Stephen G., Dib-Hajj, Sulayman D.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633991/
https://ncbi.nlm.nih.gov/pubmed/20130174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4872-09.2010
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