ERK1/2 Mitogen-Activated Protein Kinase Phosphorylates Sodium Channel Na(v)1.7 and Alters Its Gating Properties

Na(v)1.7 sodium channels can amplify weak stimuli in neurons and act as threshold channels for firing action potentials. Neurotrophic factors and pro-nociceptive cytokines that are released during development and under pathological conditions activate mitogen-activated protein kinases (MAPKs). Previ...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Stamboulian, Severine, Choi, Jin-Sung, Ahn, Hye-Sook, Chang, Yu-Wen, Tyrrell, Lynda, Black, Joel A., Waxman, Stephen G., Dib-Hajj, Sulayman D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633991/
https://ncbi.nlm.nih.gov/pubmed/20130174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4872-09.2010
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