The NADPH Oxidase NOX2 Controls Glutamate Release: A Novel Mechanism Involved in Psychosis-Like Ketamine Responses

Subanesthetic doses of NMDA receptor antagonist ketamine induce schizophrenia-like symptoms in humans and behavioral changes in rodents. Subchronic administration of ketamine leads to loss of parvalbumin-positive interneurons through reactive oxygen species (ROS), generated by the NADPH oxidase NOX2...

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Publicat a:J Neurosci
Autors principals: Sorce, Silvia, Schiavone, Stefania, Tucci, Paolo, Colaianna, Marilena, Jaquet, Vincent, Cuomo, Vincenzo, Dubois-Dauphin, Michel, Trabace, Luigia, Krause, Karl-Heinz
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633347/
https://ncbi.nlm.nih.gov/pubmed/20739552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1491-10.2010
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