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Lyn Kinase Regulates Mesolimbic Dopamine Release: Implication for Alcohol Reward

We report here that the Src family tyrosine kinase Lyn negatively regulates the release of dopamine (DA) in the mesolimbic system, as well as the rewarding properties of alcohol. Specifically, we show that RNA interference-mediated knockdown of Lyn expression results in an increase in KCl-induced DA...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Gibb, Stuart L., Jeanblanc, Jerome, Barak, Segev, Yowell, Quinn V., Yaka, Rami, Ron, Dorit
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633047/
https://ncbi.nlm.nih.gov/pubmed/21307254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5540-10.2011
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