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Lyn Kinase Regulates Mesolimbic Dopamine Release: Implication for Alcohol Reward

We report here that the Src family tyrosine kinase Lyn negatively regulates the release of dopamine (DA) in the mesolimbic system, as well as the rewarding properties of alcohol. Specifically, we show that RNA interference-mediated knockdown of Lyn expression results in an increase in KCl-induced DA...

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Pubblicato in:J Neurosci
Autori principali: Gibb, Stuart L., Jeanblanc, Jerome, Barak, Segev, Yowell, Quinn V., Yaka, Rami, Ron, Dorit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633047/
https://ncbi.nlm.nih.gov/pubmed/21307254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5540-10.2011
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