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Tumor mutational burden quantification from targeted gene panels: major advancements and challenges
Tumor mutational burden (TMB), the total number of somatic coding mutations in a tumor, is emerging as a promising biomarker for immunotherapy response in cancer patients. TMB can be quantitated by a number of NGS-based sequencing technologies. Whole Exome Sequencing (WES) allows comprehensive measu...
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| Publicado no: | J Immunother Cancer |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6631597/ https://ncbi.nlm.nih.gov/pubmed/31307554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0647-4 |
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