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QbD Based Media Development for the Production of Fab Fragments in E. coli

Ranibizumab is a biotherapeutic Fab fragment used for the treatment of age-related macular degeneration and macular oedema. It is currently expressed in the gram-negative bacterium, Escherichia coli. However, low expression levels result in a high manufacturing cost. The protein expression can be in...

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Bibliografische gegevens
Gepubliceerd in:Bioengineering (Basel)
Hoofdauteurs: Kumar, Deepak, Batra, Jyoti, Komives, Claire, Rathore, Anurag S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6631317/
https://ncbi.nlm.nih.gov/pubmed/30925730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/bioengineering6020029
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