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QbD Based Media Development for the Production of Fab Fragments in E. coli
Ranibizumab is a biotherapeutic Fab fragment used for the treatment of age-related macular degeneration and macular oedema. It is currently expressed in the gram-negative bacterium, Escherichia coli. However, low expression levels result in a high manufacturing cost. The protein expression can be in...
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| Publicado no: | Bioengineering (Basel) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6631317/ https://ncbi.nlm.nih.gov/pubmed/30925730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/bioengineering6020029 |
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