Enhancing Lentiviral and Alpharetroviral Transduction of Human Hematopoietic Stem Cells for Clinical Application

Ex vivo retroviral gene transfer into CD34(+) hematopoietic stem and progenitor cells (HSPCs) has demonstrated remarkable clinical success in gene therapy for monogenic hematopoietic disorders. However, little attention has been paid to enhancement of culture and transduction conditions to achieve r...

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Publicat a:Mol Ther Methods Clin Dev
Autors principals: Schott, Juliane W., León-Rico, Diego, Ferreira, Carolina B., Buckland, Karen F., Santilli, Giorgia, Armant, Myriam A., Schambach, Axel, Cavazza, Alessia, Thrasher, Adrian J.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629974/
https://ncbi.nlm.nih.gov/pubmed/31338385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.05.015
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