Invariant NKT Cells From Donor Lymphocyte Infusions (DLI-iNKTs) Promote ex vivo Lysis of Leukemic Blasts in a CD1d-Dependent Manner

Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment option for hematologic malignancies but relapse remains the most common cause of death. Infusion of donor lymphocytes (DLIs) can induce remission and prolong survival by exerting graft-vs.-leukemia (GVL) effects. Howeve...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jahnke, Simona, Schmid, Hannes, Secker, Kathy-Ann, Einhaus, Jakob, Duerr-Stoerzer, Silke, Keppeler, Hildegard, Schober-Melms, Irmtraud, Baur, Rebecca, Schumm, Michael, Handgretinger, Rupert, Bethge, Wolfgang, Kanz, Lothar, Schneidawind, Corina, Schneidawind, Dominik
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629940/
https://ncbi.nlm.nih.gov/pubmed/31354710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01542
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