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Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring

Exposure to maternal diabetes during pregnancy results in diabetes in offspring, but its underlying mechanisms are unclear. Here, we investigated the phenotype and molecular defects of the offspring of poorly controlled diabetic female mice generated by streptozotocin (STZ) administration. Offspring...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Inoguchi, Yukihiro, Ichiyanagi, Kenji, Ohishi, Hiroaki, Maeda, Yasutaka, Sonoda, Noriyuki, Ogawa, Yoshihiro, Inoguchi, Toyoshi, Sasaki, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629688/
https://ncbi.nlm.nih.gov/pubmed/31308441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46638-2
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