Association of Elevated Plasma Interleukin 18 level with Increased Mortality in a Clinical Trial of Statin Treatment for ARDS

OBJECTIVE: A high plasma level of inflammasome mediator interleukin 18 (IL-18) was associated with mortality in observational ARDS cohorts. Statin exposure increases both inflammasome activation and lung injury in mouse models. We tested whether randomization to statin therapy correlated with increa...

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Detalhes bibliográficos
Publicado no:Crit Care Med
Main Authors: Rogers, Angela J, Guan, Jiazhen, Trtchounian, Anna, Hunninghake, Gary M, Kaimal, Rajani, Desai, Manisha, Kozikowski, Lori-Ann, DeSouza, Lesley, Mogan, Susan, Liu, Kathleen D., Matthay, Michael A., Steingrub, Jay, Wheeler, Art, Yoon, Joo Heon, Nakahira, Kiichi, Choi, Augustine M, Baron, Rebecca M
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629502/
https://ncbi.nlm.nih.gov/pubmed/31206358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000003816
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