Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

One of the largest membrane protein families in eukaryotes are G protein-coupled receptors (GPCRs). GPCRs modulate cell physiology by activating diverse intracellular transducers, prominently heterotrimeric G proteins. The recent surge in structural data has expanded our understanding of GPCR-mediat...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Tsai, Ching-Ju, Marino, Jacopo, Adaixo, Ricardo, Pamula, Filip, Muehle, Jonas, Maeda, Shoji, Flock, Tilman, Taylor, Nicholas MI, Mohammed, Inayatulla, Matile, Hugues, Dawson, Roger JP, Deupi, Xavier, Stahlberg, Henning, Schertler, Gebhard
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Biochemistry and Chemical Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629373/
https://ncbi.nlm.nih.gov/pubmed/31251171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46041
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