Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver

Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent, and potentially morbid, disease that affects one-third of the US population. Normal liver safely accommodates lipid excess during fasting or carbohydrate restriction by increasing their oxidation to acetyl-CoA and ketones, yet lipid exc...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Fletcher, Justin A., Deja, Stanisław, Satapati, Santhosh, Fu, Xiaorong, Burgess, Shawn C., Browning, Jeffrey D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629163/
https://ncbi.nlm.nih.gov/pubmed/31012869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127737
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