Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury

Traumatic brain injury (TBI) causes cortical dysfunction and can lead to posttraumatic epilepsy. Multiple studies demonstrate that GABAergic inhibitory network function is compromised following TBI, which may contribute to hyperexcitability and motor, behavioral, and cognitive deficits. Preserving t...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Koenig, Jenny B., Cantu, David, Low, Cho, Sommer, Mary, Noubary, Farzad, Croker, Danielle, Whalen, Michael, Kong, Dong, Dulla, Chris G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629107/
https://ncbi.nlm.nih.gov/pubmed/31038473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126506
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