Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis

Atrial dysfunction is highly prevalent and associated with increased severity of heart failure. While rapid excitation-contraction coupling depends on axial junctions in atrial myocytes, the molecular basis of atrial loss of function remains unclear. We identified approximately 5-fold lower junctoph...

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Udgivet i:JCI Insight
Main Authors: Brandenburg, Sören, Pawlowitz, Jan, Eikenbusch, Benjamin, Peper, Jonas, Kohl, Tobias, Mitronova, Gyuzel Y., Sossalla, Samuel, Hasenfuss, Gerd, Wehrens, Xander H.T., Kohl, Peter, Rog-Zielinska, Eva A., Lehnart, Stephan E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629097/
https://ncbi.nlm.nih.gov/pubmed/31217359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127116
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