Critical role of IL-21 and T follicular helper cells in hypertension and vascular dysfunction

T and B cells have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce IL-21 promote germinal center (GC) B cell responses, leading to Ig production. Here we investigate the role of IL-21 and Tfh ce...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Dale, Bethany L., Pandey, Arvind K., Chen, Yuhan, Smart, Charles D., Laroumanie, Fanny, Ao, Mingfang, Xiao, Liang, Dikalova, Anna E., Dikalov, Sergey I., Elijovich, Fernando, Foss, Jason D., Barbaro, Natalia R., Van Beusecum, Justin P., Deger, Serpil M., Alsouqi, Aseel, Itani, Hana A., Norlander, Allison E., Alexander, Matthew R., Zhao, Shilin, Ikizler, T. Alp, Algood, Holly M. Scott, Madhur, Meena S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629096/
https://ncbi.nlm.nih.gov/pubmed/31013256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129278
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