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Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice

Heavy ion radiation, prevalent in outer space and relevant for radiotherapy, is densely ionizing and poses risk to stem cells that are key to intestinal homeostasis. Currently, the molecular spectrum of heavy ion radiation-induced perturbations in intestinal stem cells (ISCs), that could trigger int...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Kumar, Santosh, Suman, Shubhankar, Fornace, Albert J, Datta, Kamal
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629005/
https://ncbi.nlm.nih.gov/pubmed/31239406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102043
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