A cell topography-based mechanism for ligand discrimination by the T cell receptor

The T cell receptor (TCR) initiates the elimination of pathogens and tumors by T cells. To avoid damage to the host, the receptor must be capable of discriminating between wild-type and mutated self and nonself peptide ligands presented by host cells. Exactly how the TCR does this is unknown. In res...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fernandes, Ricardo A., Ganzinger, Kristina A., Tzou, Justin C., Jönsson, Peter, Lee, Steven F., Palayret, Matthieu, Santos, Ana Mafalda, Carr, Alexander R., Ponjavic, Aleks, Chang, Veronica T., Macleod, Charlotte, Lagerholm, B. Christoffer, Lindsay, Alan E., Dushek, Omer, Tilevik, Andreas, Davis, Simon J., Klenerman, David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628812/
https://ncbi.nlm.nih.gov/pubmed/31221762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817255116
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