A cell topography-based mechanism for ligand discrimination by the T cell receptor

The T cell receptor (TCR) initiates the elimination of pathogens and tumors by T cells. To avoid damage to the host, the receptor must be capable of discriminating between wild-type and mutated self and nonself peptide ligands presented by host cells. Exactly how the TCR does this is unknown. In res...

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Uloženo v:
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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Fernandes, Ricardo A., Ganzinger, Kristina A., Tzou, Justin C., Jönsson, Peter, Lee, Steven F., Palayret, Matthieu, Santos, Ana Mafalda, Carr, Alexander R., Ponjavic, Aleks, Chang, Veronica T., Macleod, Charlotte, Lagerholm, B. Christoffer, Lindsay, Alan E., Dushek, Omer, Tilevik, Andreas, Davis, Simon J., Klenerman, David
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628812/
https://ncbi.nlm.nih.gov/pubmed/31221762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817255116
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