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Consecutive seeding and transfer of genetic diversity in metastasis
During metastasis, only a fraction of genetic diversity in a primary tumor is passed on to metastases. We calculate this fraction of transferred diversity as a function of the seeding rate between tumors. At one extreme, if a metastasis is seeded by a single cell, then it inherits only the somatic m...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6628640/ https://ncbi.nlm.nih.gov/pubmed/31239334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819408116 |
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