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Consecutive seeding and transfer of genetic diversity in metastasis

During metastasis, only a fraction of genetic diversity in a primary tumor is passed on to metastases. We calculate this fraction of transferred diversity as a function of the seeding rate between tumors. At one extreme, if a metastasis is seeded by a single cell, then it inherits only the somatic m...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Heyde, Alexander, Reiter, Johannes G., Naxerova, Kamila, Nowak, Martin A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628640/
https://ncbi.nlm.nih.gov/pubmed/31239334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819408116
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