GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2

BACKGROUND & AIMS: Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. ME...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Gastroenterology
Главные авторы: Li, Zhi-Wei, Sun, Beicheng, Gong, Ting, Guo, Sheng, Zhang, Jianhua, Wang, Junlong, Sugawara, Atsushi, Jiang, Meisheng, Yan, Junjun, Gurary, Alexandra, Zheng, Xin, Gao, Bifeng, Xiao, Shu-Yuan, Chen, Wenlian, Ma, Chi, Farrar, Christine, Zhu, Chenjun, Chan, Owen T. M., Xin, Can, Winnicki, Andrew, Winnicki, John, Tang, Mingxin, Park, Ryan, Winnicki, Mary, Diener, Katrina, Wang, Zhanwei, Liu, Qicai, Chu, Catherine H., Arter, Zhaohui L., Yue, Peibin, Alpert, Lindsay, Hui, George S., Fei, Peiwen, Turkson, James, Yang, Wentian, Wu, Guangyu, Tao, Ailin, Ramos, Joe W., Moisyadi, Stefan, Holcombe, Randall F., Jia, Wei, Birnbaumer, Lutz, Zhou, Xiqiao, Chu, Wen-Ming
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628260/
https://ncbi.nlm.nih.gov/pubmed/30836096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.02.040
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы