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Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives
Among Uveal Melanoma (UM) driver mutations, those involving GNAQ or GNA11 genes are the most frequent, while a minor fraction of tumors bears mutations in the PLCB4 or CYSLTR2 genes. Direct inhibition of constitutively active oncoproteins deriving from these mutations is still in its infancy in UM,...
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| Udgivet i: | Cancers (Basel) |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6628160/ https://ncbi.nlm.nih.gov/pubmed/31216772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11060846 |
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