Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction

The management of locally advanced head and neck squamous cell carcinoma (HNSCC) with Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor (EGFR), achieves only moderate response rates, and clinical trials that evaluated EGFR-blockade with tyrosine kinase inhibitors (TKI)...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Job, Sylvie, de Reyniès, Aurélien, Heller, Betty, Weiss, Amélie, Guérin, Eric, Macabre, Christine, Ledrappier, Sonia, Bour, Cyril, Wasylyk, Christine, Etienne-Selloum, Nelly, Brino, Laurent, Gaiddon, Christian, Wasylyk, Bohdan, Jung, Alain C.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627901/
https://ncbi.nlm.nih.gov/pubmed/31181806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11060795
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