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The Dark Side of Fluorine

[Image: see text] Despite the perceived stability of the C–F bond, chemical instability and drug-metabolizing enzymes can lead to its cleavage. The resulting release of fluoride and formation of certain metabolites may cause safety issues and warrant the medicinal chemists’ attention.

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Yazar: Pan, Yue
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2019
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627733/
https://ncbi.nlm.nih.gov/pubmed/31312400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00235
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