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The Dark Side of Fluorine
[Image: see text] Despite the perceived stability of the C–F bond, chemical instability and drug-metabolizing enzymes can lead to its cleavage. The resulting release of fluoride and formation of certain metabolites may cause safety issues and warrant the medicinal chemists’ attention.
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| Publicado no: | ACS Med Chem Lett |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2019
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6627733/ https://ncbi.nlm.nih.gov/pubmed/31312400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00235 |
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