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Mycolactone Toxin Membrane Permeation: Atomistic versus Coarse-Grained MARTINI Simulations
Mycolactone, a cytotoxic and immunosuppressive macrolide produced by Mycobacterium ulcerans, is the central virulent factor in the skin disease Buruli ulcer. This multifunctional cytotoxin affects fundamental cellular processes such as cell adhesion, immune response, and cell death by targeting vari...
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| Veröffentlicht in: | Biophys J |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6626831/ https://ncbi.nlm.nih.gov/pubmed/31174850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.05.012 |
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