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Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1

Balanced rates of mitochondrial division and fusion are required to maintain mitochondrial function, as well as cellular and organismal homeostasis. In mammals, the cellular machines that mediate these processes are dynamin-related GTPases; the cytosolic DRP1 mediates division, while the outer membr...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Mallat, A., Uchiyama, L.F., Lewis, S.C., Fredenburg, R.A., Terada, Y., Ji, N., Nunnari, J., Tseng, C.C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6626631/
https://ncbi.nlm.nih.gov/pubmed/29601815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.03.189
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