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Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1

Balanced rates of mitochondrial division and fusion are required to maintain mitochondrial function, as well as cellular and organismal homeostasis. In mammals, the cellular machines that mediate these processes are dynamin-related GTPases; the cytosolic DRP1 mediates division, while the outer membr...

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Publicat a:Biochem Biophys Res Commun
Autors principals: Mallat, A., Uchiyama, L.F., Lewis, S.C., Fredenburg, R.A., Terada, Y., Ji, N., Nunnari, J., Tseng, C.C.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6626631/
https://ncbi.nlm.nih.gov/pubmed/29601815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.03.189
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