Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity

MICA and MICB are expressed by many human cancers as a result of cellular stress, and can tag cells for elimination by cytotoxic lymphocytes through natural killer group 2D (NKG2D) receptor activation. However, tumors evade this immune recognition pathway through proteolytic shedding of MICA and MIC...

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Publicado no:Science
Main Authors: Ferrari de Andrade, Lucas, Tay, Rong En, Pan, Deng, Luoma, Adrienne M., Ito, Yoshinaga, Badrinath, Soumya, Tsoucas, Daphne, Franz, Bettina, May, Kenneth F., Harvey, Christopher J., Kobold, Sebastian, Pyrdol, Jason W., Yoon, Charles, Yuan, Guo-Cheng, Hodi, F. Stephen, Dranoff, Glenn, Wucherpfennig, Kai W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6626532/
https://ncbi.nlm.nih.gov/pubmed/29599246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao0505
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