Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity

MICA and MICB are expressed by many human cancers as a result of cellular stress, and can tag cells for elimination by cytotoxic lymphocytes through natural killer group 2D (NKG2D) receptor activation. However, tumors evade this immune recognition pathway through proteolytic shedding of MICA and MIC...

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Gepubliceerd in:Science
Hoofdauteurs: Ferrari de Andrade, Lucas, Tay, Rong En, Pan, Deng, Luoma, Adrienne M., Ito, Yoshinaga, Badrinath, Soumya, Tsoucas, Daphne, Franz, Bettina, May, Kenneth F., Harvey, Christopher J., Kobold, Sebastian, Pyrdol, Jason W., Yoon, Charles, Yuan, Guo-Cheng, Hodi, F. Stephen, Dranoff, Glenn, Wucherpfennig, Kai W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6626532/
https://ncbi.nlm.nih.gov/pubmed/29599246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao0505
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