Multispecies study: Low dose tributyltin impairs ovarian theca cell cholesterol homeostasis through the RXR pathway in five mammalian species, including humans.

Tributyltin (TBT), an organotin chemical used as a catalyst and biocide, can stimulate cholesterol efflux in non-steroidogenic cells. Since cholesterol is the first limiting step for sex hormone production, we hypothesized that TBT disrupts intracellular cholesterol transport and impairs steroidogen...

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Dettagli Bibliografici
Pubblicato in:Arch Toxicol
Autori principali: Pu, Yong, Pearl, Sarah, Gingrich, Jeremy, Jing, Jiongjie, Martin, Denny, Murga-Zamalloa, Carlos A., Veiga-Lopez, Almudena
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625865/
https://ncbi.nlm.nih.gov/pubmed/31006824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-019-02449-y
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