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Multispecies study: Low dose tributyltin impairs ovarian theca cell cholesterol homeostasis through the RXR pathway in five mammalian species, including humans.
Tributyltin (TBT), an organotin chemical used as a catalyst and biocide, can stimulate cholesterol efflux in non-steroidogenic cells. Since cholesterol is the first limiting step for sex hormone production, we hypothesized that TBT disrupts intracellular cholesterol transport and impairs steroidogen...
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| Publié dans: | Arch Toxicol |
|---|---|
| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6625865/ https://ncbi.nlm.nih.gov/pubmed/31006824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-019-02449-y |
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