Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase

Polyketides are a large class of bioactive natural products with a wide range of structures and functions. Polyketides are biosynthesized by large, multi-domain enzyme complexes termed polyketide synthases (PKSs). One of the primary challenges when studying PKSs is the high reactivity of their poly-...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Ellis, Bryan D., Milligan, Jacob C., White, Alexander R., Duong, Vy, Altman, Pilar X., Mohammed, Lina Y., Crump, Matthew P., Crosby, John, Luo, Ray, Vanderwal, Christopher D., Tsai, Shiou-Chuan
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625825/
https://ncbi.nlm.nih.gov/pubmed/29620883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b11793
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