Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis

BACKGROUND: Syndecans are heparan sulfate proteoglycans that occur in membrane-bound or soluble forms. Syndecan-3, the least well-characterised of the syndecan family, is highly expressed on synovial endothelial cells in rheumatoid arthritis patients. Here, it binds pro-inflammatory chemokines with...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Eustace, Andrew D., McNaughton, Emily F., King, Sophie, Kehoe, Oksana, Kungl, Andreas, Mattey, Derek, Nobbs, Angela H., Williams, Neil, Middleton, Jim
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625118/
https://ncbi.nlm.nih.gov/pubmed/31300004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1939-2
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