Protease-sensitive pancreatic lipase (PNLIP) variants are associated with early onset chronic pancreatitis

OBJECTIVES. Premature activation of the digestive protease trypsin within the pancreatic parenchyma is a critical factor in the pathogenesis of pancreatitis. Alterations in genes that affect intra-pancreatic trypsin activity are associated with chronic pancreatitis (CP). Recently, carboxyl ester lip...

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Detalhes bibliográficos
Publicado no:Am J Gastroenterol
Main Authors: Lasher, Denise, Szabó, András, Masamune, Atsushi, Chen, Jian-Min, Xiao, Xunjun, Whitcomb, David C., Barmada, M. Michael, Ewers, Maren, Ruffert, Claudia, Paliwal, Sumit, Issarapu, Prachand, Bhaskar, Seema, Mani, K Radha, Chandak, Giriraj R, Laumen, Helmut, Masson, Emmanuelle, Kume, Kiyoshi, Hamada, Shin, Nakano, Eriko, Seltsam, Katharina, Bugert, Peter, Müller, Thomas, Groneberg, David A., Shimosegawa, Tooru, Rosendahl, Jonas, Férec, Claude, Lowe, Mark E., Witt, Heiko, Sahin-Tóth, Miklós
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624845/
https://ncbi.nlm.nih.gov/pubmed/30789418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14309/ajg.0000000000000051
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