Protease-sensitive pancreatic lipase (PNLIP) variants are associated with early onset chronic pancreatitis

OBJECTIVES. Premature activation of the digestive protease trypsin within the pancreatic parenchyma is a critical factor in the pathogenesis of pancreatitis. Alterations in genes that affect intra-pancreatic trypsin activity are associated with chronic pancreatitis (CP). Recently, carboxyl ester lip...

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Pubblicato in:Am J Gastroenterol
Autori principali: Lasher, Denise, Szabó, András, Masamune, Atsushi, Chen, Jian-Min, Xiao, Xunjun, Whitcomb, David C., Barmada, M. Michael, Ewers, Maren, Ruffert, Claudia, Paliwal, Sumit, Issarapu, Prachand, Bhaskar, Seema, Mani, K Radha, Chandak, Giriraj R, Laumen, Helmut, Masson, Emmanuelle, Kume, Kiyoshi, Hamada, Shin, Nakano, Eriko, Seltsam, Katharina, Bugert, Peter, Müller, Thomas, Groneberg, David A., Shimosegawa, Tooru, Rosendahl, Jonas, Férec, Claude, Lowe, Mark E., Witt, Heiko, Sahin-Tóth, Miklós
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624845/
https://ncbi.nlm.nih.gov/pubmed/30789418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14309/ajg.0000000000000051
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