ALOX12 is required for p53-mediated tumor suppression through a distinct ferroptosis pathway

It is well established that ferroptosis is primarily controlled by glutathione peroxidase 4 (GPX4). Surprisingly, we observed that p53 activation modulates ferroptotic responses without apparent effects on GPX4 function. Instead, ALOX12 inactivation diminishes p53-mediated ferroptosis induced by ROS...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Chu, Bo, Kon, Ning, Chen, Delin, Li, Tongyuan, Liu, Tong, Jiang, Le, Song, Shujuan, Tavana, Omid, Gu, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624840/
https://ncbi.nlm.nih.gov/pubmed/30962574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0305-6
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