Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non–Small Cell Lung Cancer: Results of the PEMBRO-RT Phase 2 Randomized Clinical Trial

IMPORTANCE: Many patients with advanced non–small cell lung cancer (NSCLC) receiving immunotherapy show primary resistance. High-dose radiotherapy can lead to increased tumor antigen release, improved antigen presentation, and T-cell infiltration. This radiotherapy may enhance the effects of checkpo...

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Dades bibliogràfiques
Publicat a:JAMA Oncol
Autors principals: Theelen, Willemijn S. M. E., Peulen, Heike M. U., Lalezari, Ferry, van der Noort, Vincent, de Vries, Jeltje F., Aerts, Joachim G. J. V., Dumoulin, Daphne W., Bahce, Idris, Niemeijer, Anna-Larissa N., de Langen, Adrianus J., Monkhorst, Kim, Baas, Paul
Format: Artigo
Idioma:Inglês
Publicat: American Medical Association 2019
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624814/
https://ncbi.nlm.nih.gov/pubmed/31294749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.1478
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