Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes

The inflammasome is an intracellular multi-protein complex that orchestrates the release of the pro-inflammatory cytokines IL-1β and IL-18, and a form of cell death known as pyroptosis. Tyrosine phosphorylation of the inflammasome sensors NLRP3, AIM2, NLRC4, and the adaptor protein, apoptosis-associ...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Mambwe, Bezaleel, Neo, Kurt, Javanmard Khameneh, Hanif, Leong, Keith Weng Kit, Colantuoni, Mariasilvia, Vacca, Maurizio, Muimo, Richmond, Mortellaro, Alessandra
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624653/
https://ncbi.nlm.nih.gov/pubmed/31333677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01556
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