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Brain histamine H(1) receptor occupancy after oral administration of desloratadine and loratadine

Some histamine H(1) receptor (H(1)R) antagonists induce adverse sedative reactions caused by blockade of histamine transmission in the brain. Desloratadine is a second‐generation antihistamine for treatment of allergic disorders. Its binding to brain H(1)Rs, which is the basis of sedative property o...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Nakamura, Tadaho, Hiraoka, Kotaro, Harada, Ryuichi, Matsuzawa, Takuro, Ishikawa, Yoichi, Funaki, Yoshihito, Yoshikawa, Takeo, Tashiro, Manabu, Yanai, Kazuhiko, Okamura, Nobuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624455/
https://ncbi.nlm.nih.gov/pubmed/31338198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.499
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