Identification of GSK3β inhibitor kenpaullone as a temozolomide enhancer against glioblastoma

Cancer stem cells are associated with chemoresistance and rapid recurrence of malignant tumors, including glioblastoma (GBM). Although temozolomide (TMZ) is the most effective drug treatment for GBM, GBM cells acquire resistance and become refractory to TMZ during treatment. Therefore, glioma stem c...

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Vydáno v:Sci Rep
Hlavní autoři: Kitabayashi, Tomohiro, Dong, Yu, Furuta, Takuya, Sabit, Hemragul, Jiapaer, Shabierjiang, Zhang, Jiakang, Zhang, Guangtao, Hayashi, Yasuhiko, Kobayashi, Masahiko, Domoto, Takahiro, Minamoto, Toshinari, Hirao, Atsushi, Nakada, Mitsutoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624278/
https://ncbi.nlm.nih.gov/pubmed/31296906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46454-8
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