Identification of GSK3β inhibitor kenpaullone as a temozolomide enhancer against glioblastoma

Cancer stem cells are associated with chemoresistance and rapid recurrence of malignant tumors, including glioblastoma (GBM). Although temozolomide (TMZ) is the most effective drug treatment for GBM, GBM cells acquire resistance and become refractory to TMZ during treatment. Therefore, glioma stem c...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kitabayashi, Tomohiro, Dong, Yu, Furuta, Takuya, Sabit, Hemragul, Jiapaer, Shabierjiang, Zhang, Jiakang, Zhang, Guangtao, Hayashi, Yasuhiko, Kobayashi, Masahiko, Domoto, Takahiro, Minamoto, Toshinari, Hirao, Atsushi, Nakada, Mitsutoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624278/
https://ncbi.nlm.nih.gov/pubmed/31296906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46454-8
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