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Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

Most neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) target the receptor-binding domain (RBD) of the spike glycoprotein and block its binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). The epitopes and mechanisms of mAbs targeting non-RBD regions...

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Vydáno v:	Nat Commun
Hlavní autoři:	Zhou, Haixia, Chen, Yingzhu, Zhang, Shuyuan, Niu, Peihua, Qin, Kun, Jia, Wenxu, Huang, Baoying, Zhang, Senyan, Lan, Jun, Zhang, Linqi, Tan, Wenjie, Wang, Xinquan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group UK 2019
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6624210/ https://ncbi.nlm.nih.gov/pubmed/31296843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10897-4
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Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

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