Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase

Numerous loss-of-function mutations in the progranulin (GRN) gene cause frontotemporal lobar degeneration with ubiquitin and TAR–DNA binding protein 43-positive inclusions by reduced production and secretion of GRN. Consistent with the observation that GRN has neurotrophic properties, pharmacologica...

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Publicado no:J Neurosci
Main Authors: Capell, Anja, Liebscher, Sabine, Fellerer, Katrin, Brouwers, Nathalie, Willem, Michael, Lammich, Sven, Gijselinck, Ilse, Bittner, Tobias, Carlson, Aaron M., Sasse, Florenz, Kunze, Brigitte, Steinmetz, Heinrich, Jansen, Rolf, Dormann, Dorothee, Sleegers, Kristel, Cruts, Marc, Herms, Jochen, Van Broeckhoven, Christine, Haass, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623716/
https://ncbi.nlm.nih.gov/pubmed/21289198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5757-10.2011
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