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ClC-2 Channels Regulate Neuronal Excitability, Not Intracellular Chloride Levels
Synaptic inhibition by GABA(A) receptors requires a transmembrane chloride gradient. Hyperpolarization or shunting results from outward current produced by chloride flowing down this gradient, into the cell. Chloride influx necessarily depletes the chloride gradient. Therefore, mechanisms that reple...
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| Publicado no: | J Neurosci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6623024/ https://ncbi.nlm.nih.gov/pubmed/22049427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2748-11.2011 |
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