Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

Inflammasomes are cytosolic multi-protein complexes that detect infection or cellular damage and activate the Caspase-1 (CASP1) protease. The NAIP5/NLRC4 inflammasome detects bacterial flagellin and is essential for resistance to the flagellated intracellular bacterium Legionella pneumophila. The ef...

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Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Gonçalves, Augusto V., Margolis, Shally R., Quirino, Gustavo F. S., Mascarenhas, Danielle P. A., Rauch, Isabella, Nichols, Randilea D., Ansaldo, Eduard, Fontana, Mary F., Vance, Russell E., Zamboni, Dario S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622555/
https://ncbi.nlm.nih.gov/pubmed/31251782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007886
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